Modeling Gene Regulatory Network in Fission Yeast Cell Cycle Using Hybrid Petri Nets

The complexity of gene regulatory network models stems from the fact that the models should be able to represent continuous, discrete as well as stochastic aspects of gene regulation. Hybrid stochastic Petri nets are the models, which can fairly incorporate all these aspects while keeping the model as simple as possible for biologists. This paper constructs an Hybrid Petri net model of the fission yeast cell cycle regulation mechanism. We also show some results of the regulation mechanism that is simulated and observed by implementing Petri net on available tool. We discuss several applicable questions that can be answered using hybrid Petri nets as models for genetic regulatory mechanisms.